Colchicine.

Colchicine is a highly noxious pee-soluble alkaloid found in plants of the genus Colchicum (autumn crocus, meadow saffron) with the chemical substance formula C22H25NO6. The chemical captivate up or vulgar name for colchicine is (S) N-(5,6,7,9-tetrahydro- 1,2,3, IO-tetramethoxy-9-oxobenzo [alpha] heptaien-7-yl) acetamide. The molecular exercising tip of it is 399.2 grams. Colchicine has 4 isomers,each pair has all R or S configuration.(-)-(aS,7S)-Colchicine is the vivid isomer which can interconvert betwixt aR and aS * C22H25NO6 * molecular weight is 399.4426 * melting point is 142 degrees Celsius * water solubility is less than 10/g mL at 21 degrees Celsius * pale icteric to greenish crystalline powder * photosenstive * lento hyrdolyzes in acidic solution * graduation exercise apply over 2000 age ago * derived form preparations of Colchicum autumnale * beginning depict by Padanius Dioscordes (AD 54-68), a Greek surgeon, in De Materia Medica * presently produced locally by Sigma Uses: * intercession of gout * Treatment of Familial Mediterranean Fever * minimally effective chemotherapy agent * seek use as an antimitotic agent * newborn uses universe explored - chronic hepatitis B and cirrhosis - Sweets syndrome - pediatric pericarditis - constipation Symptoms: * Nausea * diarrhea * pancytopenia * alopecia * weakness * respiratory distress - potentially fatal Is shared out into 3 phases: * demonstrate I is the G.I.

Phase - occurs inside hours of ingestion * Stage II is the multi-phase stage - cardiovascular insufficiency - respiratory insufficiency - metabolic effects - neuromuscular effects - hematologic effects * Stage lead is the recovery phase: - occurs 7 to 10 days afterwards ingestion - marked by alopecia - rally leukocytosis Mechanism of toxicity: * Metabolized in the liver - facilitated by cytochrome P450 - undergoes deacetylation and hydrolysis - converted to oxydicolchicine Recirculated in coloured: * Significant follow draped in the digestive tract *... No corporeal enthusiasm in this essay, it mearly declared things. If this was an AP essay for chemistry that would be fine. If you want to get a full essay, order it on our website: Ordercustompaper.com

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